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At the molecular level, erianin induces ferroptosis by blocking the JAK2/STAT3/SLC7A11 signaling pathway (21) while regulating the PI3K/Akt and MAPK signaling pathways (22)

A similar protection against steatosis has been previously noted in GCLM KO mice challenged with other liver toxicants 38 or stress-inducing diets 17,39

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Within the domain of kidney transplantation (KT), the application of immunosuppression may contribute to diminished immune activation and an increase in senescent cell accumulation, potentially due to impaired immune clearance mechanisms (Vavrinec et al., 2024)